ABSTRACT
The pathogenesis of colorectal cancer involves a variety of molecules and genes, among which circular RNA (circRNA) has received extensive attention in regulating the development and progression of tumors and mediating drug resistance. circNRA has been identified as tumor promoters or tumor suppressors that influence the sensitivity to chemotherapy drugs and mediate the onset and metastasis of colorectal cancer. The influence of circRNA on the drug resistance sensitivity of conventional chemotherapy has become a new direction for the research of anti-tumor chemotherapy drugs. This paper discusses the biological characteristics of circRNA and introduces the relationship between circRNA and the sensitivity to chemotherapy drugs in colorectal cancer.
ABSTRACT
<p><b>OBJECTIVE</b>To study the effects of continuous cropping obstacles on growth of Rehmannia glutinosa.</p><p><b>METHOD</b>The growth indexes, activity of root ATPase, root activity and mineral nutritional absorption were determined.</p><p><b>RESULT</b>Continuous copping decreased growth rate and declined the size of leaves. Activity of root ATPase and root activity were also inhibited.</p><p><b>CONCLUSION</b>The deficiency of source capacity is an important factor to restrain the root development of R. glutinosa with continuous cropping, the decrease of root activity and ATPase activity as well as nutritional stress of potassium and nitrogen are the reasons for the effects of continuous cropping on the growth and development of R. glutinosa.</p>
Subject(s)
Absorption , Adenosine Triphosphatases , Metabolism , Plant Roots , Metabolism , Rehmannia , Metabolism , Stress, PhysiologicalABSTRACT
<p><b>OBJECTIVE</b>To determine 5 phenolic acids in the soils around rhizosphere of Rehmannia glutinosa in the field under normal rotation and successive cropping.</p><p><b>METHOD</b>Phenolic acids related to allelopathy effect in the soils around rhizosphere of R. glutinosa were determined by HPLC.</p><p><b>RESULT</b>The growth of R. glutinosa under normal rotation was strong. During harvest, the dry weight of the root tube and the volume of the R. glutinosa under normal rotation were 6.02 and 7.71 times of the ones under successive cropping.</p><p><b>CONCLUSION</b>The seeding stage and elongating stage are the crucial periods for the autotoxic effect of the R. glutinosa under continuous cropping. During these periods, the content of coumaric acid, 4-hydroxybenzoic acid, syringic acid, and ferulic acid of R. glutinosa under successive cropping are notably negative correlation with the growth of the leaf and root tuber of R. glutinosa under successive cropping. Among them, ferulic acid plays a major role in the restriction effect on R. glutinosa under successive cropping.</p>